› 7djt

Electron Microscopy
2.8Å resolution

Human SARM1 inhibitory state bounded with inhibitor dHNN

Released:
DOI: 10.2210/pdb7djt/pdb
PDB entry 7djt coloured by chain, front view.
PDB entry 7djt coloured by chain, side view.
PDB entry 7djt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate.
Li WH, Huang K, Cai Y, Wang QW, Zhu WJ, Hou YN, Wang S, Cao S, Zhao ZY, Xie XJ, Du Y, Lee CS, Lee HC, Zhang H, Zhao YJ
OpenAccess logo Elife 10 (2021)
PMID: 33944777
Related structures: EMD-30700

Function and Biology Details

Reaction catalysed: 
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180347 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NAD(+) hydrolase SARM1 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 698 amino acids
Theoretical weight: 76.66 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6SZW1 (Residues: 27-724; Coverage: 96%)
Gene names: KIAA0524, SAMD2, SARM, SARM1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand H8L 8 x H8L
1 modified residue:
Ligand VI3 8 x VI3

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.8Å
Relevant EMDB volumes: EMD-30700
Expression system: Homo sapiens

Quick links

Citations

4 review citations

A Novel NAD Signaling Mechanism in Axon Degeneration and its Relationship to Innate Immunity.
Hopkins et al. (2021)
3 more

2 mentions without citation

Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate.
Li et al. (2021)
1 more