› 7dkh

X-ray diffraction
2.9Å resolution

Crystal structure of the Ctr9/Paf1/Cdc73/Rtf1 quaternary complex

Released:
DOI: 10.2210/pdb7dkh/pdb
Model geometry
Fit model/data
PDB entry 7dkh coloured by chain, front view.
PDB entry 7dkh coloured by chain, side view.
PDB entry 7dkh coloured by chain, top view.
Source organism: Saccharomyces cerevisiae S288C
Primary publication:
Crystal Structure of the Core Module of the Yeast Paf1 Complex.
Chen F, Liu B, Zeng J, Guo L, Ge X, Feng W, Li DF, Zhou H, Long J
J Mol Biol 434 167369 (2022)
PMID: 34852272

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-153619 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
RNA polymerase-associated protein CTR9 Chains: A, E, I
Molecule details ›
Chains: A, E, I
Length: 972 amino acids
Theoretical weight: 113.75 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
  • Canonical: P89105 (Residues: 1-972; Coverage: 90%)
Gene names: CDP1, CTR9, YOL145C
Sequence domains: Tetratricopeptide repeat
RNA polymerase II-associated protein 1 Chains: B, F, J
Molecule details ›
Chains: B, F, J
Length: 103 amino acids
Theoretical weight: 11.96 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
  • Canonical: P38351 (Residues: 1-103; Coverage: 23%)
Gene names: PAF1, YBR2016, YBR279W
Cell division control protein 73 Chains: C, G, K
RNA polymerase-associated protein RTF1 Chains: D, H, L

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 72 x MSE

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P3121
Unit cell:
a: 190.195Å b: 190.195Å c: 216.423Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.193 0.248
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Transcription Pause and Escape in Neurodevelopmental Disorders.
Eigenhuis et al. (2022)
1 more

2 mentions without citation

Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity.
Gobeil et al. (2021)
1 more