› 7dlq

X-ray diffraction
1.77Å resolution

CRYSTAL STRUCTURE OF THE COMPLEX OF LACTOPEROXIDASE WITH HYDROGEN PEROXIDE AT 1.77A RESOLUTION

Released:
DOI: 10.2210/pdb7dlq/pdb
PDB entry 7dlq coloured by chain, front view.
PDB entry 7dlq coloured by chain, side view.
PDB entry 7dlq coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Structure of a ternary complex of lactoperoxidase with iodide and hydrogen peroxide at 1.77 Å resolution.
Singh PK, Sharma P, Bhushan A, Kaur P, Sharma S, Singh TP
J Inorg Biochem 220 111461 (2021)
PMID: 33882424

Function and Biology Details

Reaction catalysed: 
2 phenolic donor + H(2)O(2) = 2 phenoxyl radical of the donor + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160329 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Lactoperoxidase Chain: A
Molecule details ›
Chain: A
Length: 595 amino acids
Theoretical weight: 67.77 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P80025 (Residues: 118-712; Coverage: 86%)
Gene name: LPO
Sequence domains: Animal haem peroxidase

Ligands and Environments


Cofactor: Ligand HEM 1 x HEM
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
8 bound ligands:
Ligand CA 1 x CA
Ligand NAG 1 x NAG
Ligand IOD 19 x IOD
Ligand GOL 1 x GOL
Ligand EDO 1 x EDO
Ligand ZN 1 x ZN
Ligand OSM 3 x OSM
Ligand PEO 1 x PEO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P21
Unit cell:
a: 54.231Å b: 79.837Å c: 77.548Å
α: 90° β: 102.67° γ: 90°
R-values:
R R work R free
0.189 0.187 0.226

Quick links

Citations

3 citation in other articles

Comments on the Discussion Forum: Oromucosal immunomodulation as clinical spectrum mitigating factor in SARS-CoV-2 infection.
Smith et al. (2022)
2 more

1 mention without citation

Cryotrapping peroxide in the active site of human mitochondrial manganese superoxide dismutase crystals for neutron diffraction.
Azadmanesh et al. (2022)