› 7dnh

Electron Microscopy
3.64Å resolution

2-fold subparticles refinement of human papillomavirus type 58 pseudovirus in complexed with the Fab fragment of 2H3

Released:
DOI: 10.2210/pdb7dnh/pdb
PDB entry 7dnh coloured by chain, front view.
PDB entry 7dnh coloured by chain, side view.
PDB entry 7dnh coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for the shared neutralization mechanism of three classes of human papillomavirus type 58 antibodies with disparate modes of binding.
He M, Chi X, Zha Z, Li Y, Chen J, Huang Y, Huang S, Yu M, Wang Z, Song S, Liu X, Wei S, Li Z, Li T, Wang Y, Yu H, Zhao Q, Zhang J, Zheng Q, Gu Y, Li S, Xia N
J Virol 95 (2021)
PMID: 33472937
Related structures: EMD-30783

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero heptamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210909 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Major capsid protein L1 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 524 amino acids
Theoretical weight: 59.1 KDa
Source organism: human papillomavirus 58
Expression system: Homo sapiens
UniProt:
  • Canonical: P26535 (Residues: 1-524; Coverage: 100%)
Gene name: L1
Sequence domains: L1 (late) protein
The light chain of 2H3 Fab fragment Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.59 KDa
Source organism: Mus musculus
Expression system: Mus musculus
The heavy chain of 2H3 Fab fragment Chain: H
Molecule details ›
Chain: H
Length: 215 amino acids
Theoretical weight: 23.07 KDa
Source organism: Mus musculus
Expression system: Mus musculus

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.64Å
Relevant EMDB volumes: EMD-30783
Expression systems:
  • Homo sapiens
  • Mus musculus

Quick links

Citations

3 citation in other articles

Implications of Persistent HPV52 and HPV58 Positivity for the Management of Cervical Lesions.
Yi et al. (2022)
2 more

1 mention without citation

Structural basis for the shared neutralization mechanism of three classes of human papillomavirus type 58 antibodies with disparate modes of binding.
He et al. (2021)