› 7dnl

Electron Microscopy
4.19Å resolution

2-fold subparticles refinement of human papillomavirus type 58 pseudovirus in complexed with the Fab fragment of A4B4

Released:
DOI: 10.2210/pdb7dnl/pdb
PDB entry 7dnl coloured by chain, front view.
PDB entry 7dnl coloured by chain, side view.
PDB entry 7dnl coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for the shared neutralization mechanism of three classes of human papillomavirus type 58 antibodies with disparate modes of binding.
He M, Chi X, Zha Z, Li Y, Chen J, Huang Y, Huang S, Yu M, Wang Z, Song S, Liu X, Wei S, Li Z, Li T, Wang Y, Yu H, Zhao Q, Zhang J, Zheng Q, Gu Y, Li S, Xia N
J Virol 95 (2021)
PMID: 33472937
Related structures: EMD-30787

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero heptamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210911 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
The light chain of A4B4 Fab fragment Chain: L
Molecule details ›
Chain: L
Length: 220 amino acids
Theoretical weight: 24.46 KDa
Source organism: Mus musculus
The heavy chain of 2H3 Fab fragment Chain: H
Molecule details ›
Chain: H
Length: 216 amino acids
Theoretical weight: 23.08 KDa
Source organism: Mus musculus
Major capsid protein L1 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 524 amino acids
Theoretical weight: 59.1 KDa
Source organism: human papillomavirus 58
Expression system: Homo sapiens
UniProt:
  • Canonical: P26535 (Residues: 1-524; Coverage: 100%)
Gene name: L1
Sequence domains: L1 (late) protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.19Å
Relevant EMDB volumes: EMD-30787
Expression system: Homo sapiens

Quick links

Citations

3 citation in other articles

Implications of Persistent HPV52 and HPV58 Positivity for the Management of Cervical Lesions.
Yi et al. (2022)
2 more

1 mention without citation

Structural basis for the shared neutralization mechanism of three classes of human papillomavirus type 58 antibodies with disparate modes of binding.
He et al. (2021)