› 7dnu

X-ray diffraction
2.24Å resolution

mRNA-decapping enzyme g5Rp with inhibitor insp6 complex

Released:
DOI: 10.2210/pdb7dnu/pdb
Model geometry
Fit model/data
PDB entry 7dnu coloured by chain, front view.
PDB entry 7dnu coloured by chain, side view.
PDB entry 7dnu coloured by chain, top view.
Source organism: African swine fever virus BA71V
Primary publication:
Structural Insight into Molecular Inhibitory Mechanism of InsP6 on African Swine Fever Virus mRNA-Decapping Enzyme g5Rp.
Yang Y, Zhang C, Li X, Li L, Chen Y, Yang X, Zhao Y, Chen C, Wang W, Zhong Z, Yang C, Huang Z, Su D
OpenAccess logo J Virol 96 e0190521 (2022)
PMID: 35481780

Function and Biology Details

Reaction catalysed: 
Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152200 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
mRNA-decapping protein g5R Chain: A
Molecule details ›
Chain: A
Length: 250 amino acids
Theoretical weight: 29.92 KDa
Source organism: African swine fever virus BA71V
Expression system: Escherichia coli
UniProt:
  • Canonical: P32092 (Residues: 1-250; Coverage: 100%)
Gene names: Ba71V-102, D250R
Sequence domains: NUDIX domain

Ligands and Environments

1 bound ligand:
Ligand IHP 1 x IHP
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P4122
Unit cell:
a: 48.432Å b: 48.432Å c: 220.077Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.171 0.233
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Structure and function of African swine fever virus proteins: Current understanding.
Yang et al. (2023)
2 other articles

1 mention without citation

Structural Insight into Molecular Inhibitory Mechanism of InsP6 on African Swine Fever Virus mRNA-Decapping Enzyme g5Rp.
Yang et al. (2022)