› 7dsq

Electron Microscopy
3.4Å resolution

Overall structure of the LAT1-4F2hc bound with 3,5-diiodo-L-tyrosine

Released:
DOI: 10.2210/pdb7dsq/pdb
PDB entry 7dsq coloured by chain, front view.
PDB entry 7dsq coloured by chain, side view.
PDB entry 7dsq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter.
Yan R, Li Y, Müller J, Zhang Y, Singer S, Xia L, Zhong X, Gertsch J, Altmann KH, Zhou Q
Cell Discov 7 16 (2021)
PMID: 33758168
Related structures: EMD-30841

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140015 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Amino acid transporter heavy chain SLC3A2 Chain: A
Molecule details ›
Chain: A
Length: 647 amino acids
Theoretical weight: 70.16 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08195 (Residues: 2-67, 68-630; Coverage: 100%)
Gene names: MDU1, SLC3A2
Sequence domains:
Large neutral amino acids transporter small subunit 1 Chain: B
Molecule details ›
Chain: B
Length: 527 amino acids
Theoretical weight: 57.19 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q01650 (Residues: 2-507; Coverage: 100%)
Gene names: CD98LC, LAT1, MPE16, SLC7A5
Sequence domains: Amino acid permease

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand TYI 1 x TYI
Ligand Y01 2 x Y01
Ligand 3PH 1 x 3PH
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-30841
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Contribution of LAT1-4F2hc in Urological Cancers via Toll-like Receptor and Other Vital Pathways.
Zhao et al. (2022)
1 more

9 mentions without citation

Chemical Approaches for Studying the Biology and Pharmacology of Membrane Transporters: The Histidine/Large Amino Acid Transporter SLC7A5 as a Benchmark.
Scalise et al. (2021)
8 more