Function and Biology Details
Reaction catalysed:
angiotensin II + H2O = angiotensin-(1-7) + L-phenylalanine.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Sodium:neurotransmitter symporter
- Peptidase M2, peptidyl-dipeptidase A
- Spike glycoprotein S2 superfamily, coronavirus
- Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus
- Spike glycoprotein S1, N-terminal domain, betacoronavirus-like
- Spike glycoprotein S2, coronavirus, heptad repeat 2
- Spike glycoprotein S2, coronavirus, heptad repeat 1
- Spike glycoprotein S2, coronavirus
9 more domains
Structure analysis Details
Assembly composition:
hetero decamer (preferred)
Assembly name:
SARS-CoV-2 Spike - human ACE2-SLC6A19 complex (preferred)
PDBe Complex ID:
PDB-CPX-144980 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Sodium-dependent neutral amino acid transporter B(0)AT1
Molecule details ›
Chains: A, C
Length: 654 amino acids
Theoretical weight: 73.29 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Sodium:neurotransmitter symporter family
Length: 654 amino acids
Theoretical weight: 73.29 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q695T7 (Residues: 2-634; Coverage: 100%)
Sequence domains: Sodium:neurotransmitter symporter family
Angiotensin-converting enzyme 2
Molecule details ›
Chains: B, D
Length: 817 amino acids
Theoretical weight: 93.97 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 817 amino acids
Theoretical weight: 93.97 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q9BYF1 (Residues: 2-17, 18-805; Coverage: 100%)
Sequence domains:
Spike glycoprotein
