› 7e7o

Electron Microscopy
3.4Å resolution

Cryo-EM structure of human ABCA4 in NRPE-bound state

Released:
DOI: 10.2210/pdb7e7o/pdb
PDB entry 7e7o coloured by chain, front view.
PDB entry 7e7o coloured by chain, side view.
PDB entry 7e7o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of substrate recognition and translocation by human ABCA4.
Xie T, Zhang Z, Fang Q, Du B, Gong X
Nat Commun 12 3853 (2021)
PMID: 34158497
Related structures: EMD-31001

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160256 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Retinal-specific phospholipid-transporting ATPase ABCA4 Chain: A
Molecule details ›
Chain: A
Length: 2317 amino acids
Theoretical weight: 261.14 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P78363 (Residues: 1-2273; Coverage: 100%)
Gene names: ABCA4, ABCR
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
3 bound ligands:
Ligand NAG 7 x NAG
Ligand 3PE 3 x 3PE
Ligand HZL 1 x HZL
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-31001
Expression system: Homo sapiens

Quick links

Citations

3 review citations

Biomedical Advances in ABCA1 Transporter: From Bench to Bedside.
Choi et al. (2023)
2 more

3 mentions without citation

Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics.
Namasivayam et al. (2021)
2 more