› 7e8g

Electron Microscopy
4.5Å resolution

CryoEM structure of human Kv4.2-DPP6S-KChIP1 complex, extracellular region

Released:
DOI: 10.2210/pdb7e8g/pdb
PDB entry 7e8g coloured by chain, front view.
PDB entry 7e8g coloured by chain, side view.
PDB entry 7e8g coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of gating modulation of Kv4 channel complexes.
Kise Y, Kasuya G, Okamoto HH, Yamanouchi D, Kobayashi K, Kusakizako T, Nishizawa T, Nakajo K, Nureki O
Nature 599 158-164 (2021)
PMID: 34552243
Related structures: EMD-31018

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154840 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dipeptidyl aminopeptidase-like protein 6 Chains: I, J, K, L
Molecule details ›
Chains: I, J, K, L
Length: 729 amino acids
Theoretical weight: 83.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P42658 (Residues: 121-849; Coverage: 84%)
Gene name: DPP6
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.5Å
Relevant EMDB volumes: EMD-31018
Expression system: Homo sapiens

Quick links

Citations

6 review citations

Sensing sound: Cellular specializations and molecular force sensors.
Qiu et al. (2022)
5 more