› 7e8h

Electron Microscopy
4.5Å resolution

CryoEM structure of human Kv4.2-DPP6S-KChIP1 complex

Released:
DOI: 10.2210/pdb7e8h/pdb
PDB entry 7e8h coloured by chain, front view.
PDB entry 7e8h coloured by chain, side view.
PDB entry 7e8h coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of gating modulation of Kv4 channel complexes.
Kise Y, Kasuya G, Okamoto HH, Yamanouchi D, Kobayashi K, Kusakizako T, Nishizawa T, Nakajo K, Nureki O
Nature 599 158-164 (2021)
PMID: 34552243
Related structures: EMD-31019

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
PDBe Complex ID:
PDB-CPX-154839 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Dipeptidyl aminopeptidase-like protein 6 Chains: J, L
Molecule details ›
Chains: J, L
Length: 757 amino acids
Theoretical weight: 86.28 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P42658 (Residues: 94-849; Coverage: 87%)
Gene name: DPP6
Sequence domains:
Dipeptidyl aminopeptidase-like protein 6 Chains: I, K
Molecule details ›
Chains: I, K
Length: 760 amino acids
Theoretical weight: 86.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P42658 (Residues: 94-849; Coverage: 87%)
Gene name: DPP6
Sequence domains:
Kv channel-interacting protein 1 Chains: F, H
Molecule details ›
Chains: F, H
Length: 180 amino acids
Theoretical weight: 21.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NZI2 (Residues: 48-227; Coverage: 79%)
Gene names: KCHIP1, KCNIP1, VABP
Sequence domains:
Potassium voltage-gated channel subfamily D member 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 494 amino acids
Theoretical weight: 55.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NZV8 (Residues: 2-495; Coverage: 78%)
Gene names: KCND2, KIAA1044
Sequence domains:
Kv channel-interacting protein 1 Chains: E, G
Molecule details ›
Chains: E, G
Length: 181 amino acids
Theoretical weight: 21.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NZI2 (Residues: 47-227; Coverage: 80%)
Gene names: KCHIP1, KCNIP1, VABP
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.5Å
Relevant EMDB volumes: EMD-31019
Expression system: Homo sapiens

Quick links

Citations

5 review citations

Sensing sound: Cellular specializations and molecular force sensors.
Qiu et al. (2022)
4 more

1 mention without citation

Kv Channel Ancillary Subunits: Where Do We Go from Here?
Abbott GW. (2022)