› 7eax

X-ray diffraction
2.55Å resolution

Crystal complex of p53-V272M and antimony ion

Released:
DOI: 10.2210/pdb7eax/pdb
Model geometry
Fit model/data
PDB entry 7eax coloured by chain, front view.
PDB entry 7eax coloured by chain, side view.
PDB entry 7eax coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Repurposing antiparasitic antimonials to noncovalently rescue temperature-sensitive p53 mutations.
Tang Y, Song H, Wang Z, Xiao S, Xiang X, Zhan H, Wu L, Wu J, Xing Y, Tan Y, Liang Y, Yan N, Li Y, Li J, Wu J, Zheng D, Jia Y, Chen Z, Li Y, Zhang Q, Zhang J, Zeng H, Tao W, Liu F, Wu Y, Lu M
Cell Rep 39 110622 (2022)
PMID: 35417717

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138105 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cellular tumor antigen p53 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 194 amino acids
Theoretical weight: 21.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P04637 (Residues: 96-289; Coverage: 49%)
Gene names: P53, TP53
Sequence domains: P53 DNA-binding domain

Ligands and Environments

2 bound ligands:
Ligand ZN 4 x ZN
Ligand SB 4 x SB
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P21
Unit cell:
a: 68.876Å b: 72.551Å c: 85.067Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.206 0.235
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

Quick links

Citations

5 review citations

Targeting p53 pathways: mechanisms, structures, and advances in therapy.
Wang et al. (2023)
4 more