› 7ejs

X-ray diffraction
2.39Å resolution

Structure of ERH-2 bound to PICS-1

Released:
DOI: 10.2210/pdb7ejs/pdb
PDB entry 7ejs coloured by chain, front view.
PDB entry 7ejs coloured by chain, side view.
PDB entry 7ejs coloured by chain, top view.
Source organism: Caenorhabditis elegans
Primary publication:
Molecular basis for PICS-mediated piRNA biogenesis and cell division.
Wang X, Zeng C, Liao S, Zhu Z, Zhang J, Tu X, Yao X, Feng X, Guang S, Xu C
Nat Commun 12 5595 (2021)
PMID: 34552083

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131233 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Enhancer of rudimentary homolog 2; Protein pid-3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 145 amino acids
Theoretical weight: 15.94 KDa
Source organism: Caenorhabditis elegans
Expression system: Escherichia coli
UniProt:
  • Canonical: Q20057 (Residues: 1-103; Coverage: 91%)
  • Canonical: O76616 (Residues: 179-200; Coverage: 7%)
Gene names: F35G12.11, Y23H5A.3, erh-2, pics-1, pid-3
Sequence domains: Enhancer of rudimentary

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P212121
Unit cell:
a: 44.825Å b: 52.528Å c: 125.119Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.201 0.238
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases.
Wu et al. (2023)
1 more