› 7elx

X-ray diffraction
2.14Å resolution

The crystal structure of CTLA-4 and Fab

Released:
DOI: 10.2210/pdb7elx/pdb
PDB entry 7elx coloured by chain, front view.
PDB entry 7elx coloured by chain, side view.
PDB entry 7elx coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Yu XJ, Wang L, Yu CF

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210688 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
heavy chain of Fab Chains: H, h
Molecule details ›
Chains: H, h
Length: 467 amino acids
Theoretical weight: 51.45 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
light chain of Fab Chains: L, l
Molecule details ›
Chains: L, l
Length: 235 amino acids
Theoretical weight: 25.72 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Cytotoxic T-lymphocyte protein 4 Chains: C, c
Molecule details ›
Chains: C, c
Length: 126 amino acids
Theoretical weight: 13.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia phage EcSzw-2
UniProt:
  • Canonical: P16410 (Residues: 36-161; Coverage: 67%)
Gene names: CD152, CTLA4
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: C2221
Unit cell:
a: 95.923Å b: 196.921Å c: 148.389Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.177 0.217
Expression systems:
  • Cricetulus griseus
  • Escherichia phage EcSzw-2

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