› 7emd

X-ray diffraction
1.7Å resolution

Mooring Stone-Like Arg114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I

Released:
DOI: 10.2210/pdb7emd/pdb
PDB entry 7emd coloured by chain, front view.
PDB entry 7emd coloured by chain, side view.
PDB entry 7emd coloured by chain, top view.
Source organisms:
Primary publication:
Mooring Stone-Like Arg114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I.
Yue C, Xiang W, Huang X, Sun Y, Xiao J, Liu K, Sun Z, Qiao P, Li H, Gan J, Ba L, Chai Y, Qi J, Liu P, Qi P, Zhao Y, Li Y, Qiu HJ, Gao GF, Gao G, Liu WJ
J Virol 96 e0137821 (2022)
PMID: 34851145

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-127592 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 275 amino acids
Theoretical weight: 31.83 KDa
Source organism: Sus scrofa
Expression system: Escherichia coli
UniProt:
  • Canonical: O19075 (Residues: 22-296; Coverage: 81%)
Gene names: SLA-1, sla-
Sequence domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.71 KDa
Source organism: Sus scrofa
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07717 (Residues: 21-118; Coverage: 100%)
Gene name: B2M
Sequence domains: Immunoglobulin C1-set domain
Hexon protein p72 Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 1.13 KDa
Source organism: uncultured virus
Expression system: Not provided
UniProt:
  • Canonical: P22776 (Residues: 97-105; Coverage: 1%)
Gene names: B646L, Ba71V-081

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P21
Unit cell:
a: 41.32Å b: 110.81Å c: 45.989Å
α: 90° β: 102.221° γ: 90°
R-values:
R R work R free
0.211 0.208 0.26
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

2 review citations

New vistas unfold: Chicken MHC molecules reveal unexpected ways to present peptides to the immune system.
Halabi et al. (2022)
1 more

1 mention without citation

Mooring Stone-Like Arg114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I.
Yue et al. (2022)