› 7erb

X-ray diffraction
1.5Å resolution

Crystal structure of human Biliverdin IX-beta reductase B with Ataluren (PTC)

Released:
DOI: 10.2210/pdb7erb/pdb
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PDB entry 7erb coloured by chain, front view.
PDB entry 7erb coloured by chain, side view.
PDB entry 7erb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IXβ Reductase B as a Novel Thrombocytopenia Therapeutic Target.
Kim M, Ha JH, Choi J, Kim BR, Gapsys V, Lee KO, Jee JG, Chakrabarti KS, de Groot BL, Griesinger C, Ryu KS, Lee D
J Med Chem 65 2548-2557 (2022)
PMID: 34957824

Function and Biology Details

Reaction catalysed: 
Reduced riboflavin + NADP(+) = riboflavin + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151614 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Flavin reductase (NADPH) Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 206 amino acids
Theoretical weight: 22.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P30043 (Residues: 1-206; Coverage: 100%)
Gene names: BLVRB, FLR, SCAN
Sequence domains: NAD(P)H-binding

Ligands and Environments


Cofactor: Ligand NAP 4 x NAP
2 bound ligands:
Ligand JBF 4 x JBF
Ligand SO4 6 x SO4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: PAL/PLS BEAMLINE 11C
Spacegroup: P212121
Unit cell:
a: 83.423Å b: 117.338Å c: 82.045Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.171 0.171 0.199
Expression system: Escherichia coli

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Citations

1 review citation

Metabolic Functions of Biliverdin IXβ Reductase in Redox-Regulated Hematopoietic Cell Fate.
Bahou et al. (2023)

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