› 7etx

X-ray diffraction
2.1Å resolution

Crystal structure of bifunctional indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (TrpC) from corynebacterium glutamicum

Released:
DOI: 10.2210/pdb7etx/pdb
Model geometry
Fit model/data
PDB entry 7etx coloured by chain, front view.
PDB entry 7etx coloured by chain, side view.
PDB entry 7etx coloured by chain, top view.
Source organism: Corynebacterium glutamicum ATCC 13032
Primary publication:
Crystal Structure and Functional Characterization of the Bifunctional N-(5'-Phosphoribosyl)anthranilate Isomerase-indole-3-glycerol-phosphate Synthase from Corynebacterium glutamicum.
Park W, Son HF, Lee D, Kim IK, Kim KJ
J Agric Food Chem 69 12485-12493 (2021)
PMID: 34657425

Function and Biology Details

Reactions catalysed: 
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O
N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139083 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tryptophan biosynthesis protein TrpCF Chain: A
Molecule details ›
Chain: A
Length: 482 amino acids
Theoretical weight: 51.6 KDa
Source organism: Corynebacterium glutamicum ATCC 13032
Expression system: Escherichia coli
UniProt:
  • Canonical: P06560 (Residues: 1-474; Coverage: 100%)
Gene names: Cgl3033, cg3362, trpC, trpCF
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: PAL/PLS BEAMLINE 7A (6B, 6C1)
Spacegroup: P43212
Unit cell:
a: 90.681Å b: 90.681Å c: 141.785Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.192 0.252
Expression system: Escherichia coli

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Citations

1 citations in other articles

Auxin-producing bacteria promote barley rhizosheath formation.
Xu et al. (2023)