› 7ezc

X-ray diffraction
3.8Å resolution

Adenosine A2a receptor mutant-I92N

Released:
DOI: 10.2210/pdb7ezc/pdb
PDB entry 7ezc coloured by chain, front view.
PDB entry 7ezc coloured by chain, side view.
PDB entry 7ezc coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of a constitutive active mutant of adenosine A2A receptor.
Cui M, Zhou Q, Xu Y, Weng Y, Yao D, Zhao S, Song G
IUCrJ 9 333-341 (2022)
PMID: 35546802

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142062 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosine receptor A2a; Soluble cytochrome b562 Chains: A, B
Molecule details ›
Chains: A, B
Length: 431 amino acids
Theoretical weight: 48.16 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P29274 (Residues: 2-208, 219-308; Coverage: 72%)
  • Canonical: P0ABE7 (Residues: 23-123; Coverage: 95%)
Gene names: ADORA2, ADORA2A, cybC
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand UKA 2 x UKA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: C2
Unit cell:
a: 71.23Å b: 175.73Å c: 112.71Å
α: 90° β: 91.22° γ: 90°
R-values:
R R work R free
0.289 0.288 0.313
Expression system: Spodoptera frugiperda

Quick links

Citations

3 citation in other articles

Cryo-EM structure of the human adenosine A2B receptor-Gs signaling complex.
Chen et al. (2022)
2 more

3 mentions without citation

Crystal structure of a constitutive active mutant of adenosine A2A receptor.
Cui et al. (2022)
2 more