› 7f6m

X-ray diffraction
2.4Å resolution

Crystal structure of APC complexed with a peptide inhibitor MAI-516

Released:
DOI: 10.2210/pdb7f6m/pdb
PDB entry 7f6m coloured by chain, front view.
PDB entry 7f6m coloured by chain, side view.
PDB entry 7f6m coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Song K, Zhang J

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150348 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Adenomatous polyposis coli protein Chain: A
Molecule details ›
Chain: A
Length: 353 amino acids
Theoretical weight: 39.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P25054 (Residues: 407-751; Coverage: 12%)
Gene names: APC, DP2.5
Sequence domains:
MAI-516 inhibitor Chain: B
Molecule details ›
Chain: B
Length: 9 amino acids
Theoretical weight: 900 Da
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

3 bound ligands:
Ligand GOL 5 x GOL
Ligand SO4 2 x SO4
Ligand PEG 2 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: C2
Unit cell:
a: 87.751Å b: 82.337Å c: 49.743Å
α: 90° β: 94.69° γ: 90°
R-values:
R R work R free
0.21 0.208 0.256
Expression system: Escherichia coli

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