› 7h6h

X-ray diffraction
1.94Å resolution

THE 1.94 A CRYSTAL STRUCTURE OF HUMAN CATHEPSIN G IN COMPLEX WITH 1-[(7-fluoronaphthalen-1-yl)methyl]-3-[[methoxycarbonyl(methyl)amino]methyl]indole-2-carboxylic acid

Released:
DOI: 10.2210/pdb7h6h/pdb
Model geometry
Fit model/data
PDB entry 7h6h coloured by chain, front view.
PDB entry 7h6h coloured by chain, side view.
PDB entry 7h6h coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Banner DW, Benz JM, Schlatter D, Hilpert H

Function and Biology Details

Reaction catalysed: 
Specificity similar to chymotrypsin C.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140091 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cathepsin G Chain: A
Molecule details ›
Chain: A
Length: 235 amino acids
Theoretical weight: 26.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08311 (Residues: 21-255; Coverage: 99%)
Gene name: CTSG
Sequence domains: Trypsin

Ligands and Environments

3 bound ligands:
Ligand ZN 1 x ZN
Ligand A1AO6 1 x A1AO6
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: BRUKER IMUS MICROFOCUS
Spacegroup: C2
Unit cell:
a: 80.21Å b: 44.73Å c: 67.27Å
α: 90° β: 107.08° γ: 90°
R-values:
R R work R free
0.174 0.171 0.232
Expression system: Escherichia coli

Quick links