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› 7jfr

X-ray diffraction
2.35Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero heptamer (preferred)
PDBe Complex ID:
PDB-CPX-237183 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Tubulin alpha-1B chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 440 amino acids
Theoretical weight: 48.97 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P81947 (Residues: 1-440; Coverage: 98%)
Sequence domains:
Tubulin beta-2B chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 445 amino acids
Theoretical weight: 50 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q6B856 (Residues: 1-445; Coverage: 100%)
Gene name: TUBB2B
Sequence domains:
Stathmin-4 Chain: E
Uncharacterized protein Chain: F
Auristatin Chain: L

Ligands and Environments

5 bound ligands:
Ligand GTP 2 x GTP
Ligand MG 5 x MG
Ligand CA 1 x CA
Ligand GDP 2 x GDP
Ligand ACP 1 x ACP
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P212121
Unit cell:
a: 104.491Å b: 155.148Å c: 181.885Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.226 0.256
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

6 review citations

Advances and Limitations of Antibody Drug Conjugates for Cancer.
Mckertish et al. (2021)
5 more