› 7jgf

Electron Microscopy
4.69Å resolution

Cryo-EM structure of P. falciparum VAR2CSA FCR3 domains DBL5 and DBL6 at 4.69 A

Released:
DOI: 10.2210/pdb7jgf/pdb
PDB entry 7jgf coloured by chain, front view.
PDB entry 7jgf coloured by chain, side view.
PDB entry 7jgf coloured by chain, top view.
Source organism: Plasmodium falciparum
Primary publication:
Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA.
Ma R, Lian T, Huang R, Renn JP, Petersen JD, Zimmerberg J, Duffy PE, Tolia NH
Nat Microbiol 6 380-391 (2021)
PMID: 33452495
Related structures: EMD-22325

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180411 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Erythrocyte membrane protein 1 Chain: A
Molecule details ›
Chain: A
Length: 2660 amino acids
Theoretical weight: 308.82 KDa
Source organism: Plasmodium falciparum
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6UDW7 (Residues: 1-2649; Coverage: 87%)
Gene name: var
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.69Å
Relevant EMDB volumes: EMD-22325
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Expanding the Chondroitin Sulfate Glycoproteome - But How Far?
Noborn et al. (2021)
1 more

2 mentions without citation

Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA.
Ma et al. (2021)
1 more