› 7jgh

Electron Microscopy
3.36Å resolution

Cryo-EM structure of P. falciparum VAR2CSA NF54 core in complex with CSA at 3.36 A

Released:
DOI: 10.2210/pdb7jgh/pdb
PDB entry 7jgh coloured by chain, front view.
PDB entry 7jgh coloured by chain, side view.
PDB entry 7jgh coloured by chain, top view.
Source organism: Plasmodium falciparum NF54
Primary publication:
Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA.
Ma R, Lian T, Huang R, Renn JP, Petersen JD, Zimmerberg J, Duffy PE, Tolia NH
Nat Microbiol 6 380-391 (2021)
PMID: 33452495
Related structures: EMD-22327

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-197783 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Erythrocyte membrane protein 1 Chain: A
Molecule details ›
Chain: A
Length: 2653 amino acids
Theoretical weight: 308.71 KDa
Source organism: Plasmodium falciparum NF54
Expression system: Homo sapiens
UniProt:
  • Canonical: W7K270 (Residues: 1-2642; Coverage: 94%)
Gene name: PFNF54_03544
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: ASG, BDP
Carbohydrate polymer
1 bound ligand:
Ligand ASG 1 x ASG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.36Å
Relevant EMDB volumes: EMD-22327
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Expanding the Chondroitin Sulfate Glycoproteome - But How Far?
Noborn et al. (2021)
1 more

5 mentions without citation

Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA.
Ma et al. (2021)
4 more