› 7jny

X-ray diffraction
1.88Å resolution

Crystal structure of CXCL13

Released:
DOI: 10.2210/pdb7jny/pdb
PDB entry 7jny coloured by chain, front view.
PDB entry 7jny coloured by chain, side view.
PDB entry 7jny coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The N-terminal length and side-chain composition of CXCL13 affect crystallization, structure and functional activity.
Rosenberg EM, Herrington J, Rajasekaran D, Murphy JW, Pantouris G, Lolis EJ
Acta Crystallogr D Struct Biol 76 1033-1049 (2020)
PMID: 33021505

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129181 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-X-C motif chemokine 13 Chain: A
Molecule details ›
Chain: A
Length: 88 amino acids
Theoretical weight: 10.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43927 (Residues: 23-109; Coverage: 100%)
Gene names: BCA1, BLC, CXCL13, SCYB13
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P3121
Unit cell:
a: 48.967Å b: 48.967Å c: 80.278Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.191 0.187 0.224
Expression system: Escherichia coli

Quick links

Citations

4 mentions without citation

Role of the CXCL13/CXCR5 Axis in Autoimmune Diseases.
Pan et al. (2022)
3 more