› 7jye

X-ray diffraction
2.55Å resolution

Human Liver Receptor Homolog-1 in Complex with 9ChoP and a Fragment of Tif2

Released:
DOI: 10.2210/pdb7jye/pdb
PDB entry 7jye coloured by chain, front view.
PDB entry 7jye coloured by chain, side view.
PDB entry 7jye coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: D'Agostino EH, Mays SG, Ortlund EA

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126310 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor subfamily 5 group A member 2 Chain: A
Molecule details ›
Chain: A
Length: 246 amino acids
Theoretical weight: 28.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O00482 (Residues: 299-541; Coverage: 45%)
Gene names: B1F, CPF, FTF, NR5A2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Nuclear receptor coactivator 2 Chain: C
Molecule details ›
Chain: C
Length: 12 amino acids
Theoretical weight: 1.48 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 740-751; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

Ligands and Environments

1 bound ligand:
Ligand VQY 1 x VQY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P3221
Unit cell:
a: 89.24Å b: 89.24Å c: 106.537Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.178 0.159 0.187
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

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