› 7jzi

X-ray diffraction
2.71Å resolution

Crystal structure of LAIR1 ectodomain (from MGD21) in complex with Plasmodium RIFIN (PF3D7_1040300) V2 domain

Released:
DOI: 10.2210/pdb7jzi/pdb
PDB entry 7jzi coloured by chain, front view.
PDB entry 7jzi coloured by chain, side view.
PDB entry 7jzi coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs.
Xu K, Wang Y, Shen CH, Chen Y, Zhang B, Liu K, Tsybovsky Y, Wang S, Farney SK, Gorman J, Stephens T, Verardi R, Yang Y, Zhou T, Chuang GY, Lanzavecchia A, Piccoli L, Kwong PD
Nat Commun 12 4226 (2021)
PMID: 34244481

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-105589 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
LAIR1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 98 amino acids
Theoretical weight: 11.09 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A6B9UEV8 (Residues: 1-97; Coverage: 83%)
Sequence domains: Immunoglobulin domain
Rifin Chains: B, D
Molecule details ›
Chains: B, D
Length: 145 amino acids
Theoretical weight: 15.13 KDa
Source organism: Plasmodium falciparum NF54
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8IJ06 (Residues: 184-328; Coverage: 41%)
Gene name: PF3D7_1040300
Sequence domains: Rifin

Ligands and Environments

1 bound ligand:
Ligand PT 2 x PT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2
Unit cell:
a: 144.409Å b: 72.178Å c: 57.917Å
α: 90° β: 91.08° γ: 90°
R-values:
R R work R free
0.244 0.24 0.281
Expression system: Homo sapiens

Quick links

Citations

1 citations in other articles

LAIR1 drives glioma progression by nuclear focal adhesion kinase dependent expressions of cyclin D1 and immunosuppressive chemokines/cytokines.
Wei et al. (2023)

2 mentions without citation

Structural basis of malaria RIFIN binding by LILRB1-containing antibodies.
Chen et al. (2021)
1 more