› 7k3z

X-ray diffraction
3.69Å resolution

P. falciparum Cpn60 D474A mutant bound to ATP

Released:
DOI: 10.2210/pdb7k3z/pdb
Model geometry
Fit model/data
PDB entry 7k3z coloured by chain, front view.
PDB entry 7k3z coloured by chain, side view.
PDB entry 7k3z coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Primary publication:
Crystal structure of P. falciparum Cpn60 bound to ATP reveals an open dynamic conformation before substrate binding.
Nguyen B, Ma R, Tang WK, Shi D, Tolia NH
OpenAccess logo Sci Rep 11 5930 (2021)
PMID: 33723304

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo heptamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184625 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
60 kDa chaperonin Chains: A, B, C, D, E, F, G
Molecule details ›
Chains: A, B, C, D, E, F, G
Length: 568 amino acids
Theoretical weight: 63.28 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8I0V3 (Residues: 68-632; Coverage: 81%)
Gene name: PF3D7_1232100
Sequence domains: TCP-1/cpn60 chaperonin family

Ligands and Environments

2 bound ligands:
Ligand MG 7 x MG
Ligand ATP 7 x ATP
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P6322
Unit cell:
a: 281.498Å b: 281.498Å c: 298.827Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.228 0.227 0.276
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Molecular Bases of Heat Stress Responses in Vegetable Crops With Focusing on Heat Shock Factors and Heat Shock Proteins.
Kang et al. (2022)

1 mention without citation

Crystal structure of P. falciparum Cpn60 bound to ATP reveals an open dynamic conformation before substrate binding.
Nguyen et al. (2021)