7k80

X-ray diffraction
2.4Å resolution

KIR3DL1*001 in complex with HLA-A*24:02 presenting the RYPLTFGW peptide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-105404 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Ig-like domain-containing protein Chains: A, D
Molecule details ›
Chains: A, D
Length: 276 amino acids
Theoretical weight: 31.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: A0A5H2UYS3 (Residues: 27-302; Coverage: 81%)
Gene name: HLA-A
Sequence domains:
Beta-2-microglobulin Chains: B, E
Molecule details ›
Chains: B, E
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
C-terminal core protein Chains: C, F
Molecule details ›
Chains: C, F
Length: 8 amino acids
Theoretical weight: 1.04 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: P04601 (Residues: 134-141; Coverage: 4%)
Gene name: nef
Killer cell immunoglobulin-like receptor 3DL1 Chains: G, H
Molecule details ›
Chains: G, H
Length: 299 amino acids
Theoretical weight: 33.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P43629 (Residues: 22-320; Coverage: 71%)
Gene names: CD158E, KIR3DL1, NKAT3, NKB1
Sequence domains: Immunoglobulin domain

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P1
Unit cell:
a: 51.265Å b: 85.017Å c: 94.832Å
α: 82.47° β: 85.97° γ: 77.92°
R-values:
R R work R free
0.201 0.198 0.249
Expression systems:
  • Escherichia coli BL21
  • Not provided
  • Homo sapiens