7k81

X-ray diffraction
2Å resolution

KIR3DL1*005 in complex with HLA-A*24:02 presenting the RYPLTFGW peptide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-105404 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: A0A5H2UYS3 (Residues: 27-302; Coverage: 81%)
Gene name: HLA-A
Sequence domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
C-terminal core protein Chain: C
Molecule details ›
Chain: C
Length: 8 amino acids
Theoretical weight: 1.04 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: P04601 (Residues: 134-141; Coverage: 4%)
Gene name: nef
Killer cell immunoglobulin-like receptor 3DL1 Chain: G
Molecule details ›
Chain: G
Length: 289 amino acids
Theoretical weight: 32.03 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P43629 (Residues: 27-315; Coverage: 68%)
Gene names: CD158E, KIR3DL1, NKAT3, NKB1
Sequence domains: Immunoglobulin domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P1
Unit cell:
a: 47.807Å b: 61.385Å c: 66.989Å
α: 94.32° β: 99.82° γ: 105.97°
R-values:
R R work R free
0.193 0.19 0.243
Expression systems:
  • Escherichia coli BL21
  • Not provided
  • Homo sapiens