› 7k8k

X-ray diffraction
2.7Å resolution

Function and Biology Details

Reaction catalysed: 
A beta-lactam + H(2)O = a substituted beta-amino acid
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161732 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-lactamase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 267 amino acids
Theoretical weight: 28.4 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WKD3 (Residues: 41-307; Coverage: 98%)
Gene names: MTCY49.07c, Rv2068c, blaA, blaC
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand 0RN 2 x 0RN
Ligand PO4 4 x PO4
Ligand TSL 2 x TSL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EUROPEAN XFEL BEAMLINE SPB/SFX
Spacegroup: P21
Unit cell:
a: 80.91Å b: 99.53Å c: 112.5Å
α: 90° β: 108.44° γ: 90°
R-values:
R R work R free
0.219 0.215 0.292
Expression system: Escherichia coli

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