› 7kbt

X-ray diffraction
4.15Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208206 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Coagulation factor VIII Chain: A
Molecule details ›
Chain: A
Length: 1467 amino acids
Theoretical weight: 168.29 KDa
Source organisms: Expression system: Cricetulus griseus
UniProt:
  • Canonical: P12263 (Residues: 1-405, 762-1820; Coverage: 37%)
  • Canonical: P00451 (Residues: 406-761, 2039-2351; Coverage: 29%)
Gene names: CF8, F8, F8C
Sequence domains:
G99 heavy chain Chain: E
Molecule details ›
Chain: E
Length: 224 amino acids
Theoretical weight: 23.95 KDa
Source organism: Mus musculus
Expression system: Mus musculus
G99 light chain Chain: F
Molecule details ›
Chain: F
Length: 214 amino acids
Theoretical weight: 23.64 KDa
Source organism: Mus musculus
Expression system: Mus musculus

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
4 bound ligands:
Ligand NAG 1 x NAG
Ligand CU 1 x CU
Ligand ZN 1 x ZN
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P41212
Unit cell:
a: 132.243Å b: 132.243Å c: 380.029Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.302 0.3 0.338
Expression systems:
  • Cricetulus griseus
  • Mus musculus

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