› 7khk

X-ray diffraction
2.34Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145426 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mast/stem cell growth factor receptor Kit Chains: A, B
Molecule details ›
Chains: A, B
Length: 335 amino acids
Theoretical weight: 37.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10721 (Residues: 545-934; Coverage: 35%)
  • Best match: P10721-4 (Residues: 27-215)
Gene names: KIT, SCFR
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

1 bound ligand:
Ligand WEJ 2 x WEJ
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P212121
Unit cell:
a: 57.984Å b: 61.906Å c: 206.769Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.247 0.245 0.285
Expression system: Escherichia coli

Quick links

Citations

9 review citations

New treatment strategies for advanced-stage gastrointestinal stromal tumours.
Klug et al. (2022)
8 more

1 mention without citation

Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA.
Teuber et al. (2024)