› 7kjn

X-ray diffraction
2.8Å resolution

CRYSTAL STRUCTURE OF HUMAN MDMX IN COMPLEX WITH D-PEPTIDE INHIBITOR (DPMI-OMEGA)

Released:
DOI: 10.2210/pdb7kjn/pdb
PDB entry 7kjn coloured by chain, front view.
PDB entry 7kjn coloured by chain, side view.
PDB entry 7kjn coloured by chain, top view.
Source organisms:
Entry authors: Tolbert WD, Pazgier M

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127324 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein Mdm4 Chain: A
Molecule details ›
Chain: A
Length: 85 amino acids
Theoretical weight: 9.58 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O15151 (Residues: 24-108; Coverage: 17%)
Gene names: MDM4, MDMX
D-PMI-omega Chains: B, C
Molecule details ›
Chains: B, C
Length: 12 amino acids
Theoretical weight: 1.69 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
8 modified residues:
Ligand DGL 6 x DGL
Ligand DPN 2 x DPN
Ligand DTR 2 x DTR
Ligand DTY 2 x DTY
Ligand DVA 2 x DVA
Ligand DLY 2 x DLY
Ligand DLE 4 x DLE
Ligand DAR 2 x DAR

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P3121
Unit cell:
a: 48.849Å b: 48.849Å c: 90.116Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.21 0.208 0.244
Expression system: Not provided

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