› 7kpw

Electron Microscopy
4.9Å resolution

Structure of the H-lobe of yeast CKM

Released:
DOI: 10.2210/pdb7kpw/pdb
PDB entry 7kpw coloured by chain, front view.
PDB entry 7kpw coloured by chain, side view.
PDB entry 7kpw coloured by chain, top view.
Source organism: Saccharomyces cerevisiae S288C
Primary publication:
Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module.
Li YC, Chao TC, Kim HJ, Cholko T, Chen SF, Li G, Snyder L, Nakanishi K, Chang CE, Murakami K, Garcia BA, Boyer TG, Tsai KL
Sci Adv 7 (2021)
PMID: 33523904
Related structures: EMD-22990

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150536 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mediator of RNA polymerase II transcription subunit 12 Chain: C
Molecule details ›
Chain: C
Length: 1427 amino acids
Theoretical weight: 167.05 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae S288C
UniProt:
  • Canonical: P25648 (Residues: 1-1427; Coverage: 100%)
Gene names: GIG1, MED12, NUT6, SRB8, SSN5, YCR081W, YCR81W/YCR80W
Sequence domains: Transcription mediator complex subunit Med12

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.9Å
Relevant EMDB volumes: EMD-22990
Expression system: Saccharomyces cerevisiae S288C

Quick links

Citations

8 review citations

Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment.
Yang et al. (2022)
7 more