Function and Biology Details
Reactions catalysed:
ATP + H(2)O = ADP + phosphate
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Heat shock protein Hsp90, N-terminal
- Heat shock protein Hsp90 family
- HSP90, C-terminal domain
- Histidine kinase/HSP90-like ATPase
- Histidine kinase/HSP90-like ATPase superfamily
- Nuclear hormone receptor
- Nuclear hormone receptor, ligand-binding domain
- Nuclear hormone receptor-like domain superfamily
5 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-137442 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Heat shock protein HSP 90-alpha
Molecule details ›
Prostaglandin E synthase 3
Glucocorticoid receptor
Molecule details ›
Chain: D
Length: 258 amino acids
Theoretical weight: 29.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Length: 258 amino acids
Theoretical weight: 29.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
- Canonical:
P04150 (Residues: 520-777; Coverage: 33%)
Sequence domains: Ligand-binding domain of nuclear hormone receptor
