› 7l50

X-ray diffraction
2.3Å resolution

Function and Biology Details

Reaction catalysed: 
Hydrolyzes glycerol monoesters of long-chain fatty acids
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189244 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Monoglyceride lipase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 320 amino acids
Theoretical weight: 35.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99685 (Residues: 1-303; Coverage: 100%)
Gene name: MGLL
Sequence domains: Serine aminopeptidase, S33

Ligands and Environments

2 bound ligands:
Ligand ACT 8 x ACT
Ligand XOM 4 x XOM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21
Unit cell:
a: 62.894Å b: 127.168Å c: 119.675Å
α: 90° β: 73.673° γ: 90°
R-values:
R R work R free
0.241 0.239 0.269
Expression system: Escherichia coli

Quick links

Citations

6 citation in other articles

Endocannabinoid signaling in the central nervous system.
Martinez Ramirez et al. (2023)
5 more

1 mention without citation

Discovery of 8-prenylnaringenin from hop (Humulus lupulus L.) as a potent monoacylglycerol lipase inhibitor for treatments of neuroinflammation and Alzheimer's disease.
Tung et al. (2021)