› 7l64

X-ray diffraction
1.35Å resolution

C-type carbohydrate-recognition domain 4 of the mannose receptor complexed with Lewis-a

Released:
DOI: 10.2210/pdb7l64/pdb
PDB entry 7l64 coloured by chain, front view.
PDB entry 7l64 coloured by chain, side view.
PDB entry 7l64 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206.
Feinberg H, Jégouzo SAF, Lasanajak Y, Smith DF, Drickamer K, Weis WI, Taylor ME
J Biol Chem 296 100368
PMID: 33545173

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149836 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Macrophage mannose receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 135 amino acids
Theoretical weight: 15.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P22897 (Residues: 646-779; Coverage: 9%)
Gene names: CLEC13D, CLEC13DL, MRC1, MRC1L1
Sequence domains: Lectin C-type domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, GAL, FUC
Carbohydrate polymer
1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-1
Spacegroup: P21
Unit cell:
a: 33.053Å b: 57.18Å c: 34.383Å
α: 90° β: 112.81° γ: 90°
R-values:
R R work R free
0.166 0.164 0.198
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

A roadmap to pulmonary delivery strategies for the treatment of infectious lung diseases.
He et al. (2022)
8 more

2 mentions without citation

Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206.
Feinberg et al. (2021)
1 more