7l7j

Electron Microscopy
3.1Å resolution

Cryo-EM structure of Hsp90:p23 closed-state complex

Released:

Function and Biology Details

Reactions catalysed:
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
ATP + H(2)O = ADP + phosphate
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-139826 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Prostaglandin E synthase 3 Chain: C
Molecule details ›
Chain: C
Length: 160 amino acids
Theoretical weight: 18.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15185 (Residues: 1-160; Coverage: 100%)
Gene names: P23, PTGES3, TEBP
Sequence domains: CS domain
Heat shock protein HSP 90-alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 732 amino acids
Theoretical weight: 84.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07900 (Residues: 1-732; Coverage: 100%)
Gene names: HSP90A, HSP90AA1, HSPC1, HSPCA
Sequence domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-23214
Expression system: Escherichia coli