› 7l83

Solution NMR

NMR solution structure of Nav1.5 DIV S3b-S4a paddle motif in DPC micelle

Released:
DOI: 10.2210/pdb7l83/pdb
PDB entry 7l83 coloured by chain, ensemble of 10 models, front view.
PDB entry 7l83 coloured by chain, ensemble of 10 models, side view.
PDB entry 7l83 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
NMR solution structure and analysis of isolated S3b-S4a motif of repeat IV of the human cardiac sodium channel
Hussein AK, Bhuiyan MH, Arshava B, Zhuang J, Poget SF
Biorxiv (2021)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172023 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium channel protein type 5 subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 37 amino acids
Theoretical weight: 4.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14524 (Residues: 1597-1633; Coverage: 2%)
Gene name: SCN5A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 64%
Refinement method: simulated annealing
Expression system: Escherichia coli

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