› 7lbp

X-ray diffraction
2.6Å resolution

Crystal structure of human Survivin bound to histone H3T3phK4ac peptide

Released:
DOI: 10.2210/pdb7lbp/pdb
Model geometry
Fit model/data
PDB entry 7lbp coloured by chain, front view.
PDB entry 7lbp coloured by chain, side view.
PDB entry 7lbp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Tip60 acetylation of histone H3K4 temporally controls chromosome passenger complex localization.
Niedzialkowska E, Liu L, Kuscu C, Mayo Z, Minor W, Strahl BD, Adli M, Stukenberg PT
OpenAccess logo Mol Biol Cell 33 br15 (2022)
PMID: 35653296

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127461 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Baculoviral IAP repeat-containing protein 5 Chains: A, C
Molecule details ›
Chains: A, C
Length: 146 amino acids
Theoretical weight: 16.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15392 (Residues: 1-142; Coverage: 100%)
Gene names: API4, BIRC5, IAP4
Sequence domains: Inhibitor of Apoptosis domain
Histone H3.1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 12 amino acids
Theoretical weight: 1.43 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P68431 (Residues: 2-13; Coverage: 9%)
Gene names: H3C1, H3C10, H3C11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3FA, H3FB, H3FC HIST1H3C, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
2 modified residues:
Ligand TPO 2 x TPO
Ligand ALY 2 x ALY

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: C2
Unit cell:
a: 113.117Å b: 70.988Å c: 83.322Å
α: 90° β: 130.04° γ: 90°
R-values:
R R work R free
0.214 0.212 0.247
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

2 citation in other articles

Epigenetic regulation limits competence of pluripotent stem cell-derived oocytes.
Aizawa et al. (2023)
1 more

1 mention without citation

Tip60 acetylation of histone H3K4 temporally controls chromosome passenger complex localization.
Niedzialkowska et al. (2022)