› 7lcv

X-ray diffraction
1.7Å resolution

Factor H enhancing human antibody fragment (Fab) to meningococcal Factor H binding protein

Released:
DOI: 10.2210/pdb7lcv/pdb
Model geometry
Fit model/data
PDB entry 7lcv coloured by chain, front view.
PDB entry 7lcv coloured by chain, side view.
PDB entry 7lcv coloured by chain, top view.
Source organisms:
Primary publication:
Two human antibodies to a meningococcal serogroup B vaccine antigen enhance binding of complement Factor H by stabilizing the Factor H binding site.
Sands NA, Beernink PT
OpenAccess logo PLoS Pathog 17 e1009655 (2021)
PMID: 34125873

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212770 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Immunoglobulin heavy chain Fd fragment Chain: A
Molecule details ›
Chain: A
Length: 227 amino acids
Theoretical weight: 23.98 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Immunoglobulin kappa light chain Chain: B
Molecule details ›
Chain: B
Length: 217 amino acids
Theoretical weight: 23.57 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Factor H binding protein Chain: C

Ligands and Environments

1 bound ligand:
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P1
Unit cell:
a: 39.47Å b: 52.37Å c: 84.56Å
α: 73.781° β: 84.482° γ: 74.173°
R-values:
R R work R free
0.24 0.24 0.27
Expression systems:
  • Cricetulus griseus
  • Escherichia coli

Quick links

Citations

1 citations in other articles

Extensive Genetic Diversity and Epidemiological Patterns of Factor H-Binding Protein Variants among Neisseria meningitidis in China.
Tan et al. (2024)

1 mention without citation

Two human antibodies to a meningococcal serogroup B vaccine antigen enhance binding of complement Factor H by stabilizing the Factor H binding site.
Sands et al. (2021)

PDB-REDO

The sliders below show the change in model quality between original PDB entry and the PDB-REDO entry

Model Geometry
 
 
Data not available
DNA/RNA Geometry
 
 
Data not available
Fit model/data
 
 
Data not available
PDB-REDO