› 7lfh

Electron Microscopy
4.2Å resolution

Cryo-EM structure of NLRP3 double-ring cage, 6-fold (12-mer)

Released:
DOI: 10.2210/pdb7lfh/pdb
PDB entry 7lfh coloured by chain, front view.
PDB entry 7lfh coloured by chain, side view.
PDB entry 7lfh coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation.
Andreeva L, David L, Rawson S, Shen C, Pasricha T, Pelegrin P, Wu H
Cell 184 6299-6312.e22 (2021)
PMID: 34861190
Related structures: EMD-23302

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185895 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NACHT, LRR and PYD domains-containing protein 3 Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 1037 amino acids
Theoretical weight: 118.8 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8R4B8 (Residues: 1-1033; Coverage: 100%)
Gene names: Cias1, Mmig1, Nalp3, Nlrp3, Pypaf1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.2Å
Relevant EMDB volumes: EMD-23302
Expression system: Homo sapiens

Quick links

Citations

36 review citations

Innate Sensors Trigger Regulated Cell Death to Combat Intracellular Infection.
Nozaki et al. (2022)
35 more

3 mentions without citation

Pharmacological Inhibition of the NLRP3 Inflammasome: Structure, Molecular Activation, and Inhibitor-NLRP3 Interaction.
Ma Q. (2023)
2 more