› 7lgw

Electron Microscopy
2.7Å resolution

Structure of human Prestin in nanodisc in the presence of NaCl

Released:
DOI: 10.2210/pdb7lgw/pdb
PDB entry 7lgw coloured by chain, front view.
PDB entry 7lgw coloured by chain, side view.
PDB entry 7lgw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular mechanism of prestin electromotive signal amplification.
Ge J, Elferich J, Dehghani-Ghahnaviyeh S, Zhao Z, Meadows M, von Gersdorff H, Tajkhorshid E, Gouaux E
Cell 184 4669-4679.e13 (2021)
PMID: 34390643
Related structures: EMD-23331

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157716 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prestin Chains: A, B
Molecule details ›
Chains: A, B
Length: 750 amino acids
Theoretical weight: 82.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P58743 (Residues: 1-744; Coverage: 100%)
Gene names: PRES, SLC26A5
Sequence domains:

Ligands and Environments

8 bound ligands:
Ligand CL 2 x CL
Ligand CLR 2 x CLR
Ligand OCT 38 x OCT
Ligand D10 33 x D10
Ligand D12 10 x D12
Ligand HEX 2 x HEX
Ligand HP6 4 x HP6
Ligand C14 4 x C14
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.7Å
Relevant EMDB volumes: EMD-23331
Expression system: Homo sapiens

Quick links

Citations

9 review citations

Sensing sound: Cellular specializations and molecular force sensors.
Qiu et al. (2022)
8 more

3 mentions without citation

Molecular mechanism of prestin electromotive signal amplification.
Ge et al. (2021)
2 more