› 7lhe

Electron Microscopy
3.3Å resolution

Structure of full-length IP3R1 channel reconstituted into lipid nanodisc in the apo-state

Released:
DOI: 10.2210/pdb7lhe/pdb
PDB entry 7lhe coloured by chain, front view.
PDB entry 7lhe coloured by chain, side view.
PDB entry 7lhe coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Cryo-EM structure of type 1 IP3R channel in a lipid bilayer
Baker MR, Fan G, Seryshev AB, Agosto MA, Baker ML, Serysheva II
Commun Biol 4 625- (2021)
Related structures: EMD-23337

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151603 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 2734 amino acids
Theoretical weight: 311.85 KDa
Source organism: Rattus norvegicus
UniProt:
  • Canonical: P29994 (Residues: 6-2739; Coverage: 99%)
Gene names: Insp3r, Itpr1
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand PLX 28 x PLX
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-23337

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