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› 7lhw

Electron Microscopy
3.7Å resolution

Structure of the LRRK2 monomer

Released:
DOI: 10.2210/pdb7lhw/pdb
PDB entry 7lhw coloured by chain, front view.
PDB entry 7lhw coloured by chain, side view.
PDB entry 7lhw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of the full-length human LRRK2.
Myasnikov A, Zhu H, Hixson P, Xie B, Yu K, Pitre A, Peng J, Sun J
Cell 184 3519-3527.e10 (2021)
PMID: 34107286
Related structures: EMD-23352

Function and Biology Details

Reaction catalysed: 
(1) L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177793 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leucine-rich repeat serine/threonine-protein kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 2527 amino acids
Theoretical weight: 286.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q5S007 (Residues: 1-2527; Coverage: 100%)
Gene names: LRRK2, PARK8
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand GDP 1 x GDP
Ligand ATP 1 x ATP
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.7Å
Relevant EMDB volumes: EMD-23352
Expression system: Homo sapiens

Quick links

Citations

15 review citations

LRRK2 and idiopathic Parkinson's disease.
Rocha et al. (2022)
14 more

20 mentions without citation

Genetic variations in GBA1 and LRRK2 genes: Biochemical and clinical consequences in Parkinson disease.
Smith et al. (2022)
19 more