› 7lip

X-ray diffraction
1.48Å resolution

X-ray structure of SPOP MATH domain (D140G)

Released:
DOI: 10.2210/pdb7lip/pdb
PDB entry 7lip coloured by chain, front view.
PDB entry 7lip coloured by chain, side view.
PDB entry 7lip coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication.
Wang D, Ma J, Botuyan MV, Cui G, Yan Y, Ding D, Zhou Y, Krueger EW, Pei J, Wu X, Wang L, Pei H, McNiven MA, Ye D, Mer G, Huang H
Sci Adv 7 (2021)
PMID: 34144977

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129109 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Speckle-type POZ protein Chain: A
Molecule details ›
Chain: A
Length: 143 amino acids
Theoretical weight: 16.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43791 (Residues: 29-166; Coverage: 37%)
Gene name: SPOP
Sequence domains: MATH domain

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: C2
Unit cell:
a: 84.766Å b: 43.45Å c: 51.026Å
α: 90° β: 123.217° γ: 90°
R-values:
R R work R free
0.182 0.18 0.205
Expression system: Escherichia coli

Quick links

Citations

6 review citations

ATM: Functions of ATM Kinase and Its Relevance to Hereditary Tumors.
Ueno et al. (2022)
5 more