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› 7lmn

X-ray diffraction
2.01Å resolution

Structure of full-length human lambda-6A light chain JTO in complex with stabilizer 26 [2-(7-(diethylamino)-4-methyl-2-oxo-2H-chromen-3-yl)ethyl (3-(1H-imidazol-4-yl)benzyl)carbamate]

Released:
DOI: 10.2210/pdb7lmn/pdb
Model geometry
Fit model/data
PDB entry 7lmn coloured by chain, front view.
PDB entry 7lmn coloured by chain, side view.
PDB entry 7lmn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design.
Yan NL, Santos-Martins D, Nair R, Chu A, Wilson IA, Johnson KA, Forli S, Morgan GJ, Petrassi HM, Kelly JW
J Med Chem 64 6273-6299 (2021)
PMID: 33939422

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-214380 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
JTO light chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 215 amino acids
Theoretical weight: 23.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

2 bound ligands:
Ligand NY3 1 x NY3
Ligand PO4 2 x PO4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P212121
Unit cell:
a: 64.028Å b: 82.131Å c: 96.451Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.187 0.239
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases.
Rinauro et al. (2024)
4 other articles

3 mentions without citation

Pharmacological stabilization of the native state of full-length immunoglobulin light chains to treat light chain amyloidosis.
Yan et al. (2023)
2 more