› 7lrf

X-ray diffraction
3.21Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187452 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Netrin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 443 amino acids
Theoretical weight: 49.58 KDa
Source organism: Gallus gallus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q90922 (Residues: 26-458; Coverage: 75%)
Gene name: NTN1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: GU4, YYJ
Carbohydrate polymer
6 bound ligands:
Ligand EDO 4 x EDO
Ligand PEG 2 x PEG
Ligand CA 2 x CA
Ligand NA 1 x NA
Ligand NHE 1 x NHE
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P212121
Unit cell:
a: 75.105Å b: 80.152Å c: 241.702Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.226 0.281
Expression system: Homo sapiens

Quick links

Citations

3 citation in other articles

Identifying the molecular basis of Laminin N-terminal domain Ca2+ binding using a hybrid approach.
Legare et al. (2024)
2 more

2 mentions without citation

The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation.
Meier et al. (2023)
1 more