› 7ls0

X-ray diffraction
3.05Å resolution

Structure of the Human ALK GRD bound to AUG

Released:
DOI: 10.2210/pdb7ls0/pdb
Model geometry
Fit model/data
PDB entry 7ls0 coloured by chain, front view.
PDB entry 7ls0 coloured by chain, side view.
PDB entry 7ls0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for ligand reception by anaplastic lymphoma kinase.
Li T, Stayrook SE, Tsutsui Y, Zhang J, Wang Y, Li H, Proffitt A, Krimmer SG, Ahmed M, Belliveau O, Walker IX, Mudumbi KC, Suzuki Y, Lax I, Alvarado D, Lemmon MA, Schlessinger J, Klein DE
Nature 600 148-152 (2021)
PMID: 34819665

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180425 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ALK and LTK ligand 2; ALK tyrosine kinase receptor Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 451 amino acids
Theoretical weight: 47.37 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9UM73 (Residues: 678-1030; Coverage: 22%)
  • Canonical: Q6UX46 (Residues: 85-152; Coverage: 53%)
Gene names: ALK, ALKAL2, FAM150B, UNQ542/PRO1097
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand CIT 2 x CIT
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P21
Unit cell:
a: 66.262Å b: 177.754Å c: 94.855Å
α: 90° β: 104.8° γ: 90°
R-values:
R R work R free
0.24 0.238 0.288
Expression system: Trichoplusia ni

Quick links

Citations

5 review citations

Nanotechnology-Based Diagnostic and Therapeutic Strategies for Neuroblastoma.
Yan et al. (2022)
4 more

1 mention without citation

Hydrogen bonding patterns and cooperativity in polyproline II helical bundles.
López-Sánchez et al. (2024)