› 7mit

Electron Microscopy
3.4Å resolution

Vascular KATP channel: Kir6.1 SUR2B propeller-like conformation 1

Released:
DOI: 10.2210/pdb7mit/pdb
PDB entry 7mit coloured by chain, front view.
PDB entry 7mit coloured by chain, side view.
PDB entry 7mit coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Vascular KATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides.
Sung MW, Yang Z, Driggers CM, Patton BL, Mostofian B, Russo JD, Zuckerman DM, Shyng SL
OpenAccess logo Proc Natl Acad Sci U S A 118 (2021)
PMID: 34711681
Related structures: EMD-23864

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179022 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
ATP-sensitive inward rectifier potassium channel 8 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 424 amino acids
Theoretical weight: 48.02 KDa
Source organism: Rattus norvegicus
Expression system: Chlorocebus aethiops
UniProt:
  • Canonical: Q63664 (Residues: 1-424; Coverage: 100%)
Gene name: Kcnj8
Sequence domains:
ATP-binding cassette sub-family C member 9 Chain: E
Molecule details ›
Chain: E
Length: 1545 amino acids
Theoretical weight: 174.49 KDa
Source organism: Rattus norvegicus
Expression system: Chlorocebus aethiops
UniProt:
  • Canonical: Q63563 (Residues: 1-1541; Coverage: 100%)
  • Best match: Q63563-2 (Residues: 1-1545)
Gene names: Abcc9, Sur2
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
6 bound ligands:
Ligand K 4 x K
Ligand ATP 5 x ATP
Ligand POV 8 x POV
Ligand PTY 8 x PTY
Ligand P5S 6 x P5S
Ligand GBM 1 x GBM
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.4Å
Relevant EMDB volumes: EMD-23864
Expression system: Chlorocebus aethiops

Quick links

Citations

5 review citations

Pericytes and the Control of Blood Flow in Brain and Heart.
Longden et al. (2023)
4 more

6 mentions without citation

Kir6.1 and SUR2B in Cantú syndrome.
McClenaghan et al. (2022)
5 more